W. Austin Gardner
More conditions of man in the last days

II Timothy 3:1 This know also, that in the last days perilous times shall come. 2 For men shall be lovers of their own selves, covetous, boasters, proud, blasphemers, disobedient to parents, unthankful, unholy, 3 Without natural affection, trucebreakers, false accusers, incontinent, fierce, despisers of those that are good, 4 Traitors, heady, highminded, lovers of pleasures more than lovers of God; 5 Having a form of godliness, but denying the power thereof: from such turn away.
Without natural affection
In the last days, the human race will suffer from this disorder. The words mean without the natural human affection. People will be callous and inhuman. They will not have normal affection for their families. They will be unloving and unforgiving.
This lack of love will destroy the family. People will be so set on themselves that they will bite the hand that feeds them. They will be able to abort their babies or leave them in a trash can. They will be heartless.
Men will so love themselves that they will not love others. The love of children for parents and parents for children, husband to wife and wife to husband, will disappear.
Truce-breakers
The word speaks of one who is unwilling to negotiate a solution to a problem with another. Unwilling to be at peace with others, The idea is being full of hate, breaking their covenant or relationship with another. Not forgiving.
Their hate is so great that they wWITHOUT SELF CONTROL: akrateis:
1Co 7:5;7:9 2Pe 2:14;2:19, 3:3; Jude 1:16, 18
2 Timothy 3 Resources - Multiple Sermons and Commentaries
KJV has "incontinent" (Webster defines it as lacking in control, one who fails to control sexual appetites)
Ungovernable in their passions
Without self control (193) (akrates from a = without + krátos = strength) is literally without strength to resist the solicitations of one's passions and so describes a man who is powerless and/or unable to govern his fleshly appetites. They are void of that inner power of self-government which is the characteristic of the disciplined man. This man has jettisoned inhibitions and shame, does not care about what people think or what happens to them because of what he does. Like a driverless car, he careens haphazardly and crashes into whatever gets in his way. These men reach a stage when, so far from controlling his passions and desires, they are totally in bondage to that life sapping habit or desire which is their "master". The body which God gave them to use for His pleasure, has tragically become a vehicle for their selfish pleasure. Few things are more tragic than a man or woman who can no longer say "no" to self and who have become hopelessly enslaved to their own cravings.
These men are "without power over self" so that they are slaves to their own passions and lusts. The body which God gave them to use for His pleasure, has become a vehicle for their own pleasure. Few things are more tragic than a man or woman who can no longer say "no" to themselves and thus are hopelessly enslaved to their own cravings.
Paul is saying that in "the last days" anything goes. No rules, no moral absolutes, no restraints of any kind. Every man does that which is right in his own eyes, and woe to the person who dares to question his “lifestyle choices.”
Jesus excoriated the religious leaders who had a "form of godliness" but lacked the power:
"Woe to you, scribes and Pharisees, hypocrites! For you clean the outside of the cup and of the dish, but inside they are full of robbery and self-indulgence” (Greek here is the related noun akrasia derived from akrates) (Mt 23:25)ill not make peace. The feud will never end. Marriages will break up. Divorce will become common. They will not forgive nor want to be forgiven. They are absolutely irreconcilable.
False accusers
Malicious gossips that seek to divide people. They slander to express their jealousy or hatred. They accuse like the accuser of the brethren, Satan.
They color the facts with lies, innuendo, and supposition. They want to destroy the good name of another.